Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

Summary: To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events that initiate aerobic glycolysis in T cells remain...

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Hlavní autoři:	Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell, Greg M. Delgoffe
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2018-02-01
Edice:	Cell Reports
Témata:	immunometabolism glycolysis PDHK1 T cell cytokine LDH
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S221112471830072X
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