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Combination therapy of itraconazole and an acylhydrazone derivative (D13) for the treatment of sporotrichosis in cats

ABSTRACT Acylhydrazone (AH) derivatives represent a novel category of anti-fungal medications that exhibit potent activity against Sporothrix sp., both in vitro and in a murine model of sporotrichosis. In this study, we demonstrated the anti-fungal efficacy of the AH derivative D13 [4-bromo-N′-(3,5-...

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Hlavní autoři: Isabella Dib Ferreira Gremião, Gabriela Reis Pereira-Oliveira, Sandro Antonio Pereira, Maria Lopes Corrêa, Luana Pereira Borba-Santos, Alessandra Lifsitch Viçosa, Ashna Garg, Krupanandan Haranahalli, Deveney Dasilva, Nivea Pereira de Sa, Gabriel S. Matos, Vanessa Silva, Cristina Lazzarini, Caroline Mota Fernandes, Kildare Miranda, Jhon Jhamilton Artunduaga Bonilla, Anna Letícia Nunes, Leonardo Nimrichter, Iwao Ojima, John Mallamo, John B. McCarthy, Maurizio Del Poeta
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2024-06-01
Edice:Microbiology Spectrum
Témata:
cats
Sporothrix
sporotrichosis
itraconazole
terbinafine
acylhydrazone
On-line přístup:https://journals.asm.org/doi/10.1128/spectrum.03967-23
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