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Distinct dynamics of mRNA LNPs in mice and nonhuman primates revealed by in vivo imaging

Abstract The characterization of vaccine distribution to relevant tissues after in vivo administration is critical to understanding their mechanisms of action. Vaccines based on mRNA lipid nanoparticles (LNPs) are now being widely considered against infectious diseases and cancer. Here, we used in v...

Ausführliche Beschreibung

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Hauptverfasser: Katia Lemdani, Romain Marlin, Céline Mayet, Vladimir Perkov, Quentin Pascal, Manon Ripoll, Francis Relouzat, Nina Dhooge, Laetitia Bossevot, Nathalie Dereuddre-Bosquet, Gihad Dargazanli, Kevin Thibaut-Duprey, Jean Haensler, Catherine Chapon, Christine Prost, Roger Le Grand
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-06-01
Schriftenreihe:npj Vaccines
Online-Zugang:https://doi.org/10.1038/s41541-024-00900-5
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