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Integrated transcriptomic and metabolomic profiles reveal the protective mechanism of modified Danggui Buxue decoction on radiation-induced leukopenia in mice

Leukopenia caused by radiation hinders the continuous treatment of cancers. Danggui Buxue Decoction (DBD) has been widely used in clinical owing to low toxicity and definite therapeutic effects to increase leukocytes. Meanwhile, icaritin (ICT) has also been proved to have the effect of boosting peri...

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Principais autores: Wei Chen, Jiayun Xin, Xintong Wei, Qianqian Ding, Yunheng Shen, Xike Xu, Yanping Wei, Yanhui Lv, Jie Wang, Zhanhong Li, Weidong Zhang, Xianpeng Zu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-08-01
coleção:Frontiers in Pharmacology
Assuntos:
leukopenia
radiation
modified Danggui Buxue decoction (MDBD)
transcriptomics
metabolomics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2023.1178724/full
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