Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase

BackgroundPulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions. Erythropoietin (EPO) attenuates pulmonary vascular remodeling in PAH. We postulated that EPO acts through mobilization of endothelial progenito...

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Detalhes bibliográficos

Principais autores:	Rosa L.E. Loon, Beatrijs eBartelds, Frank A.D.T.G. Wagener, Nada eAffara, Saffloer eMohaupt, Hans eWijnberg, Sebastiaan W.C. Pennings, Janny eTakens, Rolf M.F. Berger
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2015-08-01
Colecção:	Frontiers in Pediatrics
Assuntos:	Heme Oxygenase-1 endothelial progenitor cells pulmonary hypertension right ventricular dysfunction Neointimal Hyperplasia Pulmonary vascular remodeling
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fped.2015.00071/full
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