Decreased Levels of GSH Are Associated with Platinum Resistance in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive OC histotype. Although initially sensitive to standard platinum-based chemotherapy, most HGSOC patients relapse and become chemoresistant. We have previously demonstrated that platinum resistance is driven by a metabolic shif...

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Hauptverfasser:	Daniela Criscuolo, Rosario Avolio, Matteo Parri, Simona Romano, Paola Chiarugi, Danilo Swann Matassa, Franca Esposito
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-08-01
Schriftenreihe:	Antioxidants
Schlagworte:	ovarian cancer platinum resistance GSH reactive oxygen species (ROS)
Online-Zugang:	https://www.mdpi.com/2076-3921/11/8/1544
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