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Phenotypic heterogeneity shapes phage resistance and cocktail efficacy in Klebsiella pneumoniae

ABSTRACT The emergence of phage-resistant bacteria poses a significant challenge to the success of phage therapy. Although phage cocktails can delay resistance, their efficacy relies on the ability to target the full spectrum of resistant variants, which are often more diverse than those represented...

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Hlavní autoři: Lucas Mora-Quilis, Rafael Sanjuán, Pilar Domingo-Calap
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2026-06-01
Edice:Microbiology Spectrum
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On-line přístup:https://journals.asm.org/doi/10.1128/spectrum.02261-25
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