Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid

Introduction Primary biliary cholangitis (PBC) is a rare chronic cholestatic disease that despite current therapy has significant ongoing unmet needs, including risks of cirrhosis and life-impairing symptoms. The current treatment approach is a step-up model, wherein first-line therapy, ursodeoxycho...

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Hauptverfasser:	Thomas Chadwick, Emma Culver, Palak Trivedi, James Wason, Richard Aspinall, Doug Thorburn, Holly Fisher, David E J Jones, George Mells, Michael Heneghan, Guruprasad Aithal, Helen C Hancock, Jessica Dyson, Rachel Smith, Sarah Dunn, Ciara Kennedy, Stephen T Barclay, Mo Christie, Faye Wolstenhulme, Lysbeth Evans, Ann Breeze Konkoth, Rebecca Wafer, Sam Moody, Emma Burton, Annie Banham, Fiona Hale
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMJ Publishing Group 2026-03-01
Schriftenreihe:	BMJ Open
Online-Zugang:	https://bmjopen.bmj.com/content/16/3/e113812.full
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