Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation

Abstract Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likely to be a major culprit in the toxicity of FUS mutations. Thus, preventing cytopla...

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Detalhes bibliográficos

Principais autores:	Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-09-01
coleção:	Molecular Neurodegeneration
Assuntos:	Amyotrophic lateral sclerosis Fronto-temporal dementia Mouse models RNA-binding proteins FUS Autoregulation
Acesso em linha:	https://doi.org/10.1186/s13024-021-00477-w
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