Genomic landscape of pediatric germ cell tumors reveals oncogenic mutations and copy number alterations

IntroductionGerm cell tumors (GCTs) are rare neoplasms affecting approximately 3.5% of all pediatric patients, with diverse histological subtypes. Despite their clinical and biological heterogeneity, pediatric GCTs generally exhibit a low mutational burden. Compared to adult GCTs, however, the molec...

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Autors principals:	Janaina Mello Soares Galvão, Ana Flavia Souza Peres Bezerra, Felipe Antonio de Oliveira Garcia, Ana Glenda Santarosa Vieira, Eduardo Caetano Albino da Silva, André van Helvoort Lengert, Rui Manuel Reis, Luiz Fernando Lopes, Adriane Feijó Evangelista, Mariana Tomazini Pinto
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-02-01
Col·lecció:	Frontiers in Oncology
Matèries:	germ cell tumor pediatric tumor whole-exome sequencing mutation copy number alteration
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1689022/full
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