ZNF350 gene polymorphisms promote the response to Peg-IFNα therapy through JAK-STAT signaling pathway in patients with chronic hepatitis B

BackgroundThe varying individual responses to Pegylated interferon-α (Peg-IFNα) in patients with chronic hepatitis B (CHB) pose significant hurdles in treatment optimization, and the underlying mechanisms remain unclear.ObjectiveWe aimed to identify genetic polymorphisms influencing the efficacy of...

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Autori principali:	Jianhui Guo, Shaoying Guo, Tianbin Chen, Yongbin Zeng, Ya Fu, Qishui Ou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2024-11-01
Serie:	Frontiers in Immunology
Soggetti:	hepatitis B virus single nucleotide polymorphism zinc finger protein 350 Peg-IFNα therapeutic effect
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1488055/full
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