Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABAA receptor gamma2 subunit in the cerebellum

Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the receptor, especially on those that form extrasynaptic...

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Principais autores:	Elli Leppä, Anni-Maija Tuulikki Linden, M. Isabel Aller, Peer Wulff, Olga Vekovischeva, Bernhard Lüscher, Hartmut Lüddens, William Wisden, Esa R Korpi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2016-10-01
Series:	Frontiers in Pharmacology
Assuntos:	Cerebellum Purkinje Cells Neurosteroids extrasynaptic GABAA receptors motor performance
Acceso en liña:	http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00403/full
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