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Pyropheophorbide-α methyl ester-mediated photodynamic therapy triggers pyroptosis in osteosarcoma cells via the ROS/caspase-3/GSDME pathway

Background: Pyropheophorbide-α methyl ester-mediated photodynamic therapy(MPPa-PDT) is a candidate treatment for solid tumors, including osteosarcoma. Pyroptosis has garnered significant attention in cancer research due to its pro-inflammatory and immunomodulatory nature. This study investigated the...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Qiu Huang, Yong Tao, Ye Zhang, Yuxing Chen, Fuqiang Tan, Yunsheng Ou
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-12-01
Schriftenreihe:Photodiagnosis and Photodynamic Therapy
Schlagworte:
MPPa-PDT
Pyroptosis
Osteosarcoma
ROS
Mitochondria
PDT
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S1572100024004630
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