Highly frequent <it>PIK3CA </it>amplification is associated with poor prognosis in gastric cancer

<p>Abstract</p> <p>Background</p> <p>The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival in human tumorigenesis, including gastric cancer. <it>PIK3CA </it>mutations and amplification are two major causes of overactivation of this pathway in hu...

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Prif Awduron:	Shi Jing, Yao Demao, Liu Wei, Wang Na, Lv Hongjun, Zhang Guanjun, Ji Meiju, Xu Li, He Nongyue, Shi Bingyin, Hou Peng
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2012-02-01
Cyfres:	BMC Cancer
Pynciau:	Gastric cancer PI3K/Akt pathway <it>PIK3CA </it>mutations <it>PIK3CA </it>amplification Poor survival
Mynediad Ar-lein:	http://www.biomedcentral.com/1471-2407/12/50
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