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A T Cell Suppressive Circuitry Mediated by CD39 and Regulated by ShcC/Rai Is Induced in Astrocytes by Encephalitogenic T Cells

Multiple sclerosis is an autoimmune disease caused by autoreactive immune cell infiltration into the central nervous system leading to inflammation, demyelination, and neuronal loss. While myelin-reactive Th1 and Th17 are centrally implicated in multiple sclerosis pathogenesis, the local CNS microen...

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Principais autores: Cristina Ulivieri, Domiziana De Tommaso, Francesca Finetti, Barbara Ortensi, Giuliana Pelicci, Mario Milco D'Elios, Clara Ballerini, Cosima T. Baldari
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2019-05-01
סדרה:Frontiers in Immunology
נושאים:
astrocyte
EAE
neuroinflammation
molecular adaptor
T cell signaling
ATP-degrading enzyme
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fimmu.2019.01041/full
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