Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)

Natural products have continued to offer tremendous opportunities for drug development, as they have long been used in traditional medicinal systems. SHP2 has served as an anticancer target. To identify novel SHP2 inhibitors with potential anticancer activity, we screened a library containing 658 na...

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Hlavní autoři:	Se Jeong Kwon, Dohee Ahn, Hyun-Mo Yang, Hyo Jin Kang, Sang J. Chung
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-02-01
Edice:	Molecules
Témata:	natural products protein tyrosine phosphatase (PTP) src homology region 2-domain-containing phosphatase-1 (SHP-1) src homology region 2-containing protein tyrosine phosphatase-2 (SHP2) polyphyllin D leukemia
On-line přístup:	https://www.mdpi.com/1420-3049/26/4/848
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