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Bayesian multivariate genetic analysis improves translational insights

Summary: While lipid traits are known essential mediators of cardiovascular disease, few approaches have taken advantage of their shared genetic effects. We apply a Bayesian multivariate size estimator, mash, to GWAS of four lipid traits in the Million Veterans Program (MVP) and provide posterior me...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sarah M. Urbut, Satoshi Koyama, Whitney Hornsby, Rohan Bhukar, Sumeet Kheterpal, Buu Truong, Margaret S. Selvaraj, Benjamin Neale, Christopher J. O’Donnell, Gina M. Peloso, Pradeep Natarajan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2023-10-01
Schriftenreihe:iScience
Schlagworte:
Human genetics
Biocomputational method
Computational bioinformatics
Genomic analysis
Association analysis
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2589004223019314
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