Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment

Cellular energy metabolism plays a crucial role in the regulation of macrophage polarization and in the execution of immune functions. A recent study showed that Slc6a8-mediated creatine uptake from exogenous supplementation modulates macrophage polarization, yet little is known about the role of th...

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Hlavní autoři:	Li Yu, Lingwei Wang, Guang Hu, Laibin Ren, Chen Qiu, Shun Li, Xiaohui Zhou, Shanze Chen, Rongchang Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-09-01
Edice:	Frontiers in Immunology
Témata:	macrophage polarization creatine glycine amidinotransferase (GATM) asthma
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.937331/full
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