Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

With the aim to identify novel inhibitors of parasitic nematode thymidylate synthase (TS), we screened in silico an in-house library of natural compounds, taking advantage of a model of nematode TS three-dimensional (3D) structure and choosing candidate compounds potentially capable of enzyme bindin...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Piotr Maj, Mattia Mori, Justyna Sobich, Joanna Markowicz, Łukasz Uram, Zbigniew Zieliński, Deborah Quaglio, Andrea Calcaterra, Ylenia Cau, Bruno Botta, Wojciech Rode
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2020-06-01
Rangatū:	Molecules
Ngā marau:	thymidylate synthase inhibitor nematocidal activity cytotoxicity xanthones
Urunga tuihono:	https://www.mdpi.com/1420-3049/25/12/2894
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!