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Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

The development of clinically relevant anti-microRNA antisense oligonucleotides (anti-miRNA ASOs) remains a major challenge. One promising configuration of anti-miRNA ASOs called “tiny LNA (tiny Locked Nucleic Acid)” is an unusually small (~8-mer), highly chemically modified anti-miRNA ASO with high...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tsuyoshi Yamamoto, Yahiro Mukai, Fumito Wada, Chisato Terada, Yukina Kayaba, Kaho Oh, Asako Yamayoshi, Satoshi Obika, Mariko Harada–Shiba
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-05-01
Schriftenreihe:Pharmaceutics
Schlagworte:
tiny LNA
miR-122
GalNAc
Ligand-targeted drug delivery system
antisense oligonucleotide
Online-Zugang:https://www.mdpi.com/1999-4923/13/6/817
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