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Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway

Abstract Background Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we aimed to identify the target antigen for 12C7 and confirm its role in LCS...

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Principais autores: Xiong Shu, Kai-Yue Cao, Hui-Qi Liu, Long Yu, Li-Xin Sun, Zhi-Hua Yang, Cheng-Ai Wu, Yu-Liang Ran
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-02-01
Serier:Stem Cell Research & Therapy
Fag:
α-Enolase
Monoclonal antibody
Tumor-associated antigens
Cancer stem cells
Lung cancer
Online adgang:https://doi.org/10.1186/s13287-021-02160-9
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