Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disordersResearch in context

Summary: Background: Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by progressive degeneration of the optic nerve that leads to irreversible visual impairment. Multiple epidemiological studies suggest an association between POAG and major neurodegenerative disorders (Alzhe...

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Hauptverfasser:	Santiago Diaz-Torres, Weixiong He, Jackson Thorp, Sahba Seddighi, Sean Mullany, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Anthony P. Khawaja, Alex W. Hewitt, Jamie E. Craig, David A. Mackey, Janey L. Wiggs, Cornelia van Duijn, Michelle K. Lupton, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-06-01
Schriftenreihe:	EBioMedicine
Schlagworte:	Glaucoma Brain morphology Genetics Neurodegenerative disorders Dementia MAPT
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2352396423001809
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