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Non-canonical STING–PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response

Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis, while the underlying mechanism remains elusive. Here, we report that the non-canonical stimulator of interferon genes (STING)–PKR-like ER kinase (PERK) pathway was significantly activated in both human and...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xuesong Li, Xiang Chen, Longbin Zheng, Minghong Chen, Yunjia Zhang, Ruigong Zhu, Jiajing Chen, Jiaming Gu, Quanwen Yin, Hong Jiang, Xuan Wu, Xian Ji, Xin Tang, Mengdie Dong, Qingguo Li, Yuanqing Gao, Hongshan Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2023-12-01
Schriftenreihe:Acta Pharmaceutica Sinica B
Schlagworte:
Endothelial dysfunction
Inflammation
Mitochondrial DNA
STING
ROS
PERK
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211383523003192
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