The sigma factor σ54 (rpoN) functions as a global regulator of antibiotic resistance, motility, metabolism, and virulence in Clostridioides difficile

Clostridioides difficile, a major cause of antibiotic-associated diarrhea and pseudomembranous colitis, is increasingly resistant to antibiotics and poses a significant threat due to its regulated virulence. The alternative sigma factor σ54 (rpoN) is known to regulate gene expression broadly, affect...

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Detalhes bibliográficos

Principais autores:	Ying Yang, Tingyu Huang, Junyi Yang, Ruirui Shao, Luhong Shu, Ping Ling, Yingjun Lu, Weihao Ma, Jian Liao, Zhizhong Guan, Guzhen Cui, Xiaolan Qi, Wei Hong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-04-01
Colecção:	Frontiers in Microbiology
Assuntos:	Clostridioides difficile sigma-54 rpoN antibiotic resistance motility toxin production
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1569627/full
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