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Filter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection

Abstract Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is increasing evidence to suggest that it is an early process in dementia which may be exacerbated by peripheral infection. Filter-exchange imaging (FEXI) is an MRI technique for measuring trans-membrane water ex...

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Principais autores: Yolanda Ohene, William J. Harris, Elizabeth Powell, Nina W. Wycech, Katherine F. Smethers, Samo Lasič, Kieron South, Graham Coutts, Andrew Sharp, Catherine B. Lawrence, Hervé Boutin, Geoff J. M. Parker, Laura M. Parkes, Ben R. Dickie
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-04-01
Serier:Fluids and Barriers of the CNS
Fag:
MRI
FEXI
Blood–brain barrier
BBB water permeability
BBB water exchange
Infection
Online adgang:https://doi.org/10.1186/s12987-023-00422-7
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