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Using ΔK280 Tau<sub>RD</sub> Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy

Misfolded aggregation of the hyperphosphorylated microtubule binding protein Tau in the brain is a pathological hallmark of Alzheimer’s disease (AD). Tau aggregation downregulates brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase B (TRKB) signaling and leads to neurotoxicity. There...

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Principais autores: Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2023-01-01
סדרה:Biomolecules
נושאים:
Alzheimer’s disease
BDNF-TRKB signaling
TRKB agonist
heterocyclic compound
Tau cell model
גישה מקוונת:https://www.mdpi.com/2218-273X/13/2/219
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