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The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABAA Receptors Containing γ1, γ2, and γ3 Subunits

γ-Aminobutyric-acid type A (GABAA) receptors expressing the γ1 or γ3 subunit are only found within a few regions of the brain, some of which are involved in sleep. No known compounds have been reported to selectively target γ1- or γ3-containing GABAA receptors. Pharmacological assessments of this ar...

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Main Authors: Grant Richter, Vivian W. Y. Liao, Philip K. Ahring, Mary Chebib
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
GABAA receptors
Z-drugs
modulators
γ1 subunit
γ3 subunit
zolpidem
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.599812/full
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