Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer

Abstract Background Ovarian cancer (OC) is a prevalent malignancy in the female reproductive system, and developing effective targeted therapies for this disease remains challenging. The aim of this study was to use clinically-relevant OC models to evaluate the therapeutic effectiveness of RC48, an...

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Principais autores:	Weisong Li, Kai Zhang, Wenjun Wang, Yuanyuan Liu, Jianming Huang, Meihong Zheng, Ling Li, Xinyu Zhang, Minjuan Xu, Guofang Chen, Liefeng Wang, Shuyong Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-02-01
Series:	Journal of Experimental & Clinical Cancer Research
Assuntos:	HER2 VEGFR Antibody drug conjugate RC48 Cediranib Maleate Synergetic effect
Acceso en liña:	https://doi.org/10.1186/s13046-024-02981-5
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