Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy

Ubiquitin (Ub) and ubiquitin-like (Ubl) pathways are critical post-translational modifications that determine whether functional proteins are degraded or activated/inactivated. To date, >600 associated enzymes have been reported that comprise a hierarchical task network (e.g., E1–E2–E3 cascade enzym...

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Hauptverfasser:	Yanyu Jiang, Shuaishuai Ni, Biying Xiao, Lijun Jia
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-11-01
Schriftenreihe:	Acta Pharmaceutica Sinica B
Schlagworte:	Ub and Ubl modifications Ub-activating enzyme Ub-conjugating enzyme Ub ligase Multiomics analyses Drug discovery
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211383523002812
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