A self-perpetuating neuron-intrinsic GSDMD–mtDNA–AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury

IntroductionTraumatic brain injury (TBI) is a leading cause of mortality and long-term disability worldwide, producing acute neurological deficits and lasting cognitive impairment. Post-injury neuroinflammation is a principal driver of secondary damage and contributes substantially to TBI-induced co...

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Ngā kaituhi matua:	Tian Li, Siyu Huang, Junjun Zhang, Xueer Liu, Lihong Zhu, Yue Li, Runmin Lin, Xiaoxuan Chen, Kangsheng Li, Weiqiang Chen, Jiangtao Sheng
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2026-06-01
Rangatū:	Frontiers in Immunology
Ngā marau:	AIM2 inflammasome cognitive impairment GSDMD mtDNA traumatic brain injury
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1867920/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!