Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner

Abstract Background Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose phosphate pathway (PPP), a branch of glycolysis, is an important metabolic pathway for the survival and biosynthesis of cancer cells. Transketolase (TKT) is a key enzyme in the non-oxidative phase of PPP...

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Autors principals:	Zhaoyu Qin, Chan Xiang, Fan Zhong, Yang Liu, Qiongzhu Dong, Kai Li, Wenhao Shi, Chen Ding, Lunxiu Qin, Fuchu He
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-04-01
Col·lecció:	Journal of Experimental & Clinical Cancer Research
Matèries:	Hepatocellular carcinoma Pentose phosphate pathway Transketolase Nuclear localization Non-metabolic function
Accés en línia:	http://link.springer.com/article/10.1186/s13046-019-1131-1
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