13C-Metabolic flux analysis detected a hyperoxemia-induced reduction of tricarboxylic acid cycle metabolism in granulocytes during two models of porcine acute subdural hematoma and hemorrhagic shock

IntroductionSupplementation with increased inspired oxygen fractions has been suggested to alleviate the harmful effects of tissue hypoxia during hemorrhagic shock (HS) and traumatic brain injury. However, the utility of therapeutic hyperoxia in critical care is disputed to this day as controversial...

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Autores principales:	Eva-Maria Wolfschmitt, Josef Albert Vogt, Melanie Hogg, Ulrich Wachter, Nicole Stadler, Thomas Kapapa, Thomas Datzmann, David Alexander Christian Messerer, Andrea Hoffmann, Michael Gröger, Franziska Münz, René Mathieu, Simon Mayer, Tamara Merz, Pierre Asfar, Enrico Calzia, Peter Radermacher, Fabian Zink
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2024-01-01
Colección:	Frontiers in Immunology
Materias:	Bayesian modeling glucose metabolism glutamine utilization hyperoxia immunometabolism mass isotopomer distribution
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1319986/full
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