Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

Abstract Background The underlying mechanism of brain glucose hypometabolism, an invariant neurodegenerative feature that tightly correlates with cognitive impairment and disease progression of Alzheimer’s disease (AD), remains elusive. Methods Positron emission tomography with 2-[18F]fluoro-2-deoxy...

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Detalhes bibliográficos

Principais autores:	Shaoming Sang, Xiaoli Pan, Zhichun Chen, Fan Zeng, Shumei Pan, Huimin Liu, Lirong Jin, Guoqiang Fei, Changpeng Wang, Shuhua Ren, Fangyang Jiao, Weiqi Bao, Weiyan Zhou, Yihui Guan, Yiqiu Zhang, Hongcheng Shi, Yanjiang Wang, Xiang Yu, Yun Wang, Chunjiu Zhong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-03-01
coleção:	Alzheimer’s Research & Therapy
Assuntos:	Alzheimer’s disease Brain glucose metabolism Thiamine diphosphate Amyloid-β Position emission tomography
Acesso em linha:	http://link.springer.com/article/10.1186/s13195-018-0354-2
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