Enhancement of spinosad production in Saccharopolyspora spinosa by overexpression of the complete 74-kb spinosyn gene cluster

Abstract Background Spinosad, a secondary metabolite produced by Saccharopolyspora spinosa, is a polyketide macrolide insecticide with low toxicity and environmental friendliness. Owing to the high level of DNA methylation and unclear regulatory mechanisms, gene engineering to increase spinosad prod...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Lu Gan, Zhengyu Zhang, Jingtao Chen, Zhichun Shen, Wujie Chen, Shaoxin Chen, Jiyang Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-05-01
Schriftenreihe:	Microbial Cell Factories
Schlagworte:	Saccharopolyspora spinosa Spinosad Overexpression Spinosyn gene cluster
Online-Zugang:	https://doi.org/10.1186/s12934-025-02724-x
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