Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors
The tryptophan to kynurenine metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and tryptophan-2,3-dioxy...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015-01-01
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| coleção: | Frontiers in Immunology |
| Assuntos: | |
| Acesso em linha: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00673/full |
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