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Investigation of mitochondrial phenotypes in motor neurons derived by direct conversion of fibroblasts from familial ALS subjects

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of motor neurons, leading to fatal muscle paralysis. Familial forms of ALS (fALS) account for approximately 10% of cases. Alterations of mitochondrial functions have been proposed to contribute to disease pathoge...

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Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Evan Woo, Faiza Tasnim, Hibiki Kawamata, Giovanni Manfredi, Csaba Konrad
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Publishing Group 2025-11-01
Rangatū:Cell Death and Disease
Urunga tuihono:https://doi.org/10.1038/s41419-025-08126-6
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