Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions.
Microhomology (MH) flanking a DNA double-strand break (DSB) drives chromosomal rearrangements but its role in mutagenesis has not yet been analyzed. Here we determined the mutation frequency of a URA3 reporter gene placed at multiple locations distal to a DSB, which is flanked by different sizes (15...
Na minha lista:
| Principais autores: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2017-04-01
|
| Serier: | PLoS Genetics |
| Online adgang: | http://europepmc.org/articles/PMC5413072?pdf=render |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|