An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon

ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates canonical cell entry via ACE2 and has also been implicated as an activator of a diverse range of signaling pathways. Here, we present evidence that the RGD (Arg-Gly-Asp) motif within the receptor-bin...

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Bibliografske podrobnosti

Principais autores:	Nicholas P. Gracie, Anupriya Aggarwal, Rachel Luo, Mitchell Spicer, Sobia Idrees, Caroline L. Ashley, Sibel Alca, Timothy Ison, Megan C. Steain, Karishma Patel, Rezwan Siddiquee, Jason K. K. Low, Joel P. Mackay, Christopher E. Denes, G. Gregory Neely, Alen Faiz, Stuart G. Turville, Timothy P. Newsome
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2025-09-01
Serija:	Journal of Virology
Teme:	SARS-CoV-2 TGF-β coronavirus COVID-19 RGD (Arg-Gly-Asp) integrins
Online dostop:	https://journals.asm.org/doi/10.1128/jvi.00435-25
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