Loss of DJ-1 alleviates microglia-mediated neuroinflammation in Parkinson’s disease via autophagy-lysosomal degradation of NLRP3

ObjectiveThis study aimed to investigate the role and underlying mechanism of DJ-1 in regulating NLRP3 inflammasome-mediated neuroinflammation during Parkinson’s disease.MethodsWe used LPS to stimulate primary microglia in vitro and performed stereotactic injection of LPS into the substantia nigra o...

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Bibliografski detalji

Glavni autori:	Qianqian Miao, Tiantian Wang, Haoran Wang, Yanxia Yu, Xing Jin
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2025-09-01
Serija:	Frontiers in Immunology
Teme:	Parkinson’s disease neuroinflammation DJ-1 (PARK7) NLRP3 inflammasome microglia
Online pristup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1656729/full
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