Semi-Synthesis, Cytotoxic Evaluation, and Structure—Activity Relationships of Brefeldin A Derivatives with Antileukemia Activity

Brefeldin A (<b>1</b>), a potent cytotoxic natural macrolactone, was produced by the marine fungus <i>Penicillium</i> sp. (HS-N-29) from the medicinal mangrove <i>Acanthus ilicifolius</i>. Series of its ester derivatives <b>2</b>–<b>16</b> were designed and semi-synthesized, and their structures wer...

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Autori principali:	Xu-Xiu Lu, Yao-Yao Jiang, Yan-Wei Wu, Guang-Ying Chen, Chang-Lun Shao, Yu-Cheng Gu, Ming Liu, Mei-Yan Wei
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-12-01
Serie:	Marine Drugs
Soggetti:	brefeldin A ester derivative chronic myelogenous leukemia BCR-ABL proliferation inhibition molecular modeling
Accesso online:	https://www.mdpi.com/1660-3397/20/1/26
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