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Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse

Sorting nexin 27 (SNX27) association to the retromer complex mediates intracellular trafficking of cargoes containing PSD95/Dlg1/ZO-1 (PDZ)-binding C-terminal sequences from endosomes to the cell surface, preventing their lysosomal degradation. Antigen recognition by T lymphocyte leads to the format...

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Principais autores: Natalia González-Mancha, Cristina Rodríguez-Rodríguez, Andrés Alcover, Isabel Merida
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2021.814570/full
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