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Simultaneous single-cell proteomics and epigenetic analysis of histone deacetylase inhibition in human cells

Abstract Single-cell proteomics by mass spectrometry (SCP) is an emerging technology in which hundreds or thousands of proteins can be directly quantified in typical human cells. As the proteins detected and quantified by SCP are heavily biased toward proteins of highest abundance, chromatin protein...

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Autore principale: Benjamin C. Orsburn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-12-01
Serie:Communications Biology
Accesso online:https://doi.org/10.1038/s42003-025-09452-3
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