Age-related loss of phospholipid asymmetry in APPNLh/APPNLh x PS-1P264L/PS-1P264L human double mutant knock-in mice: Relevance to Alzheimer disease

Using APPNLh/APPNLh x PS-1P246L/PS-1P246L human double knock-in (APP/PS-1) mice, we examined whether phosphatidylserine (PtdSer) asymmetry is significantly altered in brain of this familial Alzheimer disease mouse model in an age-dependent manner as a result of oxidative stress, toxic Aβ(1-42) oligo...

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主要な著者:	Miranda L. Bader Lange, Daret St. Clair, William R. Markesbery, Christa M. Studzinski, M. Paul Murphy, D. Allan Butterfield
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2010-04-01
シリーズ:	Neurobiology of Disease
主題:	Amyloid precursor protein (APP) Presenilin-1 (PS-1) Familial Alzheimer disease (FAD) Phosphatidylserine (PtdSer) Phospholipid asymmetry Oxidative stress
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S0969996110000069
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