Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis

Arginine, due to the guanidine moiety, increases peptides’ hydrophilicity and enables interactions with charged molecules, but at the same time, its presence in a peptide chain might reduce its permeability through biological membranes. This might be resolved by temporary coverage of the peptide cha...

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Principais autores:	Mladena Glavaš, Agata Gitlin-Domagalska, Natalia Ptaszyńska, Dominika Starego, Sylwia Freza, Dawid Dębowski, Aleksandra Helbik-Maciejewska, Anna Łęgowska, Chaim Gilon, Krzysztof Rolka
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2023-11-01
叢編:	Molecules
主題:	arginine building blocks increased lipophilicity SPPS vasopressin prodrugs
在線閱讀:	https://www.mdpi.com/1420-3049/28/23/7780
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