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The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the pre-synaptic and inhibitory metabotropic glutamate receptor type 7 (mGlu7) reduces spontaneous seizures.We tested LSP2-9166, a recently devel...

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Principais autores: Benoit Girard, Pola Tuduri, Maria Paula Moreno, Sophie Sakkaki, Cedric Barboux, Tristan Bouschet, Annie Varrault, Jihane Vitre, Isabelle McCort-Tranchepain, Julien Dairou, Francine Acher, Laurent Fagni, Nicola Marchi, Julie Perroy, Federica Bertaso
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019-09-01
Colecção:Neurobiology of Disease
Assuntos:
Epilepsy
Neuropharmacology
Metabotropic glutamate receptor
Animal models
Seizures
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996119301056
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