Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade
Angiopoietin-2 (ANG2/ANGPT2) is a context-dependent TIE2 receptor agonist/antagonist and proangiogenic factor. Although ANG2 neutralization improves tumor angiogenesis and growth inhibition by vascular endothelial growth factor (VEGF)-A signaling blockade, the mechanistic underpinnings of such thera...
Gardado en:
| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2014-08-01
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| Series: | Cell Reports |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S2211124714005610 |
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