Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

Accurate annotation of protein coding regions is essential for understanding how genetic information is translated into function. We describe riboHMM, a new method that uses ribosome footprint data to accurately infer translated sequences. Applying riboHMM to human lymphoblastoid cell lines, we iden...

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Detalles Bibliográficos

Autores principales:	Anil Raj, Sidney H Wang, Heejung Shim, Arbel Harpak, Yang I Li, Brett Engelmann, Matthew Stephens, Yoav Gilad, Jonathan K Pritchard
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2016-05-01
Colección:	eLife
Materias:	ribosome profiling translation hidden Markov models upstream ORF noncoding RNA
Acceso en línea:	https://elifesciences.org/articles/13328
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