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Quantitative Determination of Four Potential Genotoxic Impurities in the Active Pharmaceutical Ingredients in TSD-1 Using UPLC-MS/MS

A novel method of ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed for the identification and quantification of four potential genotoxic impurities (PGIs) in the active pharmaceutical ingredients of TSD-1, a novel P2Y<sub>12</sub> receptor antagonist. Four...

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Principais autores: Taiyu Wang, Hailong Yang, Jie Yang, Ningjie Guo, Guodong Wu, Xueyu Xu, Ming An
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-06-01
coleção:Molecules
Assuntos:
UPLC-MS/MS
genotoxic impurities
TSD-1
active pharmaceutical ingredients
quantitation
method validation
Acesso em linha:https://www.mdpi.com/1420-3049/27/13/4129
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