ENPP3 drives ccRCC progression by cGAMP hydrolysis and STING–IFN suppression

Objective Clear-cell renal cell carcinoma (ccRCC) is an immune-desert tumor. This study investigates the role of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a potential therapeutic target and immune-checkpoint enzyme in ccRCC.Methods ENPP3 expression and its link to hypoxia and pro...

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Principais autores:	Jiaxing Ma, Yayun Wu, Guangzheng Lin, Xin Sun, Hao Geng, Tao Zhang, Dexin Yu
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis Group 2026-12-01
叢編:	Cancer Biology & Therapy
主題:	ENPP3 ccRCC cGAMP-STING type I interferon tumor-associated macrophage
在線閱讀:	https://www.tandfonline.com/doi/10.1080/15384047.2026.2632995
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