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Profiling and functional data on the developing olfactory/GnRH system reveal cellular and molecular pathways essential for this process and potentially relevant for the Kallmann syndrome

During embryonic development, immature neurons in the olfactory epithelium (OE) extend axons through the nasal mesenchyme, to contact projection neurons in the olfactory bulb. Axon navigation is accompanied by migration of the GnRH+ neurons, which enter the anterior forebrain and home in the septo-h...

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Principais autores: Giulia eGaraffo, Paolo eProvero, Ivan eMolineris, Patrizia ePinciroli, Clelia ePeano, Cristina eBattaglia, Daniela eTomaiuolo, Talya eEtzion, Yoav eGothilf, Massimo Mattia Santoro, Giorgio Roberto Merlo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013-12-01
Serier:Frontiers in Endocrinology
Fag:
Extracellular Matrix Proteins
Kallmann Syndrome
transcription profiling
GnRH neurons
olfactory development
disease gene prediction
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00203/full
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